Integrin beta 7 Antikörper (C-Term)

Produktnummer ABIN952915

Produktdetails anti-Integrin beta 7 Antikörper

Target: Integrin beta 7 (ITGB7)

Bindungsspezifität: AA 736-765, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Integrin beta 7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody recognizes Human Integrin beta-7 (C-term).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 736-765 amino acids from the C-terminal region of Human Integrin beta-7

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Andere Bezeichnung: Integrin beta-7 (ITGB7 Produkte)

Synonyme: Ly69 antikoerper, integrin beta 7 antikoerper, integrin subunit beta 7 antikoerper, integrin, beta 7 antikoerper, Itgb7 antikoerper, ITGB7 antikoerper

Hintergrund: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.Synonyms: ITGB7, Integrin alpha 4 beta 7, Integrin beta-P, LPAM-1, LPAM1, M290 IEL antigen

Molekulargewicht: 86903 Da

Gen-ID: 3695

NCBI Accession: NP_000880

Pathways: Integrin Complex