Haptoglobin Antikörper (Middle Region)

Produktnummer ABIN952678

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Haptoglobin in WB, FACS, IF, IHC (p) und EIA. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für Haptoglobin Antikörper (Middle Region) (ABIN952678)

Target: Haptoglobin (HP)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Haptoglobin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Haptoglobin Antikörper

Bindungsspezifität: AA 299-326, Middle Region

Spezifität: This antibody recognizes Human Haptoglobin (Center).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 299-326 amino acids from the Central region of Human Haptoglobin Genename: HP

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Haptoglobin Antikörper (ABIN952678)

Higham, Baker, Jackson, Shah, Lea, Singh: "Dysregulation of the CD163-Haptoglobin Axis in the Airways of COPD Patients." in: Cells, Vol. 11, Issue 1, (2022) (PubMed).

Details zu Haptoglobin

Target: Haptoglobin (HP)

Andere Bezeichnung: Haptoglobin

Hintergrund: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 45205 Da

Gen-ID: 3240

NCBI Accession: NP_001119574

Pathways: Transition Metal Ion Homeostasis