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GPC2 Antikörper (N-Term)

GPC2 Reaktivität: Human, Maus WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN952586
  • Target Alle GPC2 Antikörper anzeigen
    GPC2 (Glypican 2 (GPC2))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    AA 136-165, N-Term
    Reaktivität
    • 26
    • 12
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 27
    Kaninchen
    Klonalität
    • 27
    Polyklonal
    Konjugat
    • 10
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GPC2 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    Recognizes GPC2 (N-term).
    Aufreinigung
    Protein A column followed by peptide Affinity purification
    Immunogen
    KLH conjugated synthetic peptide between 136-165 amino acids from the N-terminal region of Human GPC2 (NP_689955.1) Genename: GPC2
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product GPC2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    GPC2 (Glypican 2 (GPC2))
    Andere Bezeichnung
    GPC2 (GPC2 Produkte)
    Synonyme
    2410016G05Rik antikoerper, glypican 2 antikoerper, glypican 2 (cerebroglycan) antikoerper, GPC2 antikoerper, Gpc2 antikoerper
    Hintergrund
    The glypicans (GPC) constitute a family of heparan sulfate proteoglycans that are attached to the cell surface by a lycosylphosphatidylinositol (GPI) anchor. Six members of this family have been identified in mammals (GPC1-GPC6). All glypican core proteins contain an N-terminal signal peptide, a large globular cysteine rich domain (CRD) with 14 invariant cysteine residues, a stalklike region containing the heparan sulfate attachment sites, and a C-terminal GPI attachment site. Based on the degree of their amino acid sequence similarity, two subfamilies of glypicans have been defined. One subfamily (sharing from 35-63 % sequence homology) includes GPC1, 2, 4, and 6, while the second subfamily (sharing 54 % sequence identity) includes GPC3 and 5. Proteins between the two subfamilies also share 17-25 % sequence similarity (1-4). Glypicans are widely expressed in adult and fetal tissues. During embryonic development, the expression level of the various glypicans changes in a stage and tissue specific manner. GPC2, also known as cerebroglycan, is primarily expressed in developing neuronal tissues including the brain, spinal cord, dorsal root ganglia, and cranial nerves. It is found on the tracts of actively growing axons (5). Cell surface GPC2 binds midkine, indicating midkine GPC2 interaction may participate in neuronal cell migration and neurite outgrowth (6).Synonyms: Glypican-2
    Gen-ID
    221914
    NCBI Accession
    NP_689955
    Pathways
    Glycosaminoglycan Metabolic Process
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