Cyclin T1 Antikörper (Middle Region)

Produktnummer ABIN951765

Dieses Anti-Cyclin T1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Cyclin T1 in WB, FACS, IHC (p) und EIA. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für Cyclin T1 Antikörper (Middle Region) (ABIN951765)

Target: Cyclin T1 (CCNT1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin T1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-Cyclin T1 Antikörper

Bindungsspezifität: AA 256-285, Middle Region

Spezifität: This antibody reacts to CCNT1.

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 256-285 amino acids from the Central region of human CCNT1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Cyclin T1 Antikörper (ABIN951765)

Kapasi, Clark, Tran, Spector: "Recruitment of cdk9 to the immediate-early viral transcriptosomes during human cytomegalovirus infection requires efficient binding to cyclin T1, a threshold level of IE2 86, and active transcription." in: Journal of virology, Vol. 83, Issue 11, pp. 5904-17, (2009) (PubMed).

Details zu Cyclin T1

Target: Cyclin T1 (CCNT1)

Andere Bezeichnung: Cyclin T1

Hintergrund: CCNT1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.Synonyms: CCNT1, CycT1, Cyclin-T, Cyclin-T1

Molekulargewicht: 80685 Da

Gen-ID: 904

NCBI Accession: NP_001231