CPT1C Antikörper (C-Term)

Produktnummer ABIN951689

Der Kaninchen Polyklonal Anti-CPT1C-Antikörper wurde für WB, FACS und EIA validiert. Er ist geeignet, CPT1C in Proben von Human zu detektieren.

Kurzübersicht für CPT1C Antikörper (C-Term) (ABIN951689)

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPT1C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Produktdetails anti-CPT1C Antikörper

Bindungsspezifität: AA 759-790, C-Term

Spezifität: This antibody reacts to CPT1C.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 759-790 amino acids from the C-terminal region of human CPT1C

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CPT1C

Target: CPT1C (Carnitine Palmitoyltransferase 1C (CPT1C))

Andere Bezeichnung: CPT1C / CPT1-B

Hintergrund: The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.Synonyms: CPT IC, Carnitine O-palmitoyltransferase 1, Carnitine palmitoyltransferase 1C, brain isoform

Molekulargewicht: 90989 Da

Gen-ID: 126129

NCBI Accession: NP_001129524

Pathways: AMPK Signaling, Monocarboxylic Acid Catabolic Process