CD8B Antikörper (Biotin)

Produktnummer ABIN951402

Der Biotin-konjugierte Ratte Monoklonal anti-CD8B Antikörper (Klon CT-CD8b) (ABIN951402) detektiert spezifisch CD8B in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für CD8B Antikörper (Biotin) (ABIN951402)

Target: CD8B (CD8b Molecule (CD8B))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD8B Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Klon: CT-CD8b

Produktdetails anti-CD8B Antikörper (Biotin)

Spezifität: This anti-mouse CD8β Chain monoclonal antibody reacts with the mouse CD8 chain. The CD8 β Chain is also named Ly-3. The CD8 chain associates with the CD8 chain to form the CD8 / heterodimer on MHC class I restricted T-cells (cytotoxic T cells) and most thymocytes1. Since a small subset of T cells (IEL cells) express CD8 / homodimers rather than CD8 / heterodimers, investigators should use an antibody directed against the CD8 chain (CL168B, clone CT-CD8a) to definitively label mouse CD8 cells.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. Should this product contain a precipitate we recommend microcentrifugation before use.

Details zu CD8B

Target: CD8B (CD8b Molecule (CD8B))

Andere Bezeichnung: CD8 beta

Hintergrund: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain

Gen-ID: 12526

NCBI Accession: NP_033988

UniProt: P10300

Pathways: T-Zell Rezeptor Signalweg