CHN2 Antikörper (Middle Region)

Produktnummer ABIN950491

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch CHN2 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CHN2 Antikörper (Middle Region) (ABIN950491)

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-CHN2 Antikörper

Bindungsspezifität: AA 162-192, Middle Region

Spezifität: This antibody detects ARHGAP3/CHN2.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse

Aufreinigung: Purified through a protein A column; followed by peptide affinity purification.

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region ( between 162-192aa) of human CHN2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CHN2

Target: CHN2 (Chimerin (Chimaerin) 2 (CHN2))

Andere Bezeichnung: ARHGAP3 / CHN2

Hintergrund: The CHN2 gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.Synonyms: BCH, Beta-chimaerin, Beta-chimerin, Rho GTPase-activating protein 3

Gen-ID: 1124

NCBI Accession: NP_001035025