ADAM9 Antikörper (Extracellular Domain)

Produktnummer ABIN950269

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch ADAM9 in WB. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für ADAM9 Antikörper (Extracellular Domain) (ABIN950269)

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser ADAM9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 7D10

Produktdetails anti-ADAM9 Antikörper

Bindungsspezifität: Extracellular Domain

Aufreinigung: Protein A/G Affinity Chromatography

Immunogen: Purified Recombinant ADAM9 extracellular domain.

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered PBS solution, None

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 months.

Haltbarkeit: 6 months

Details zu ADAM9

Target: ADAM9 (ADAM Metallopeptidase Domain 9 (ADAM9))

Andere Bezeichnung: ADAM9 / MDC9

Hintergrund: ADAM9, also known as MDC9 or meltrin γ, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. Like other membrane-anchored ADAMs, ADAM9 consists of a pro domain with a cysteine switch and furin cleavage sequence, a catalytic domain with the zinc-binding site and Metturn expected for reprolysins, a disintegrin like domain, a cysteine-rich domain, an EGF-like domain, a transmembrane domain, and the cytoplasmic domain. ADAM9 is able to cleave peptides corresponding to cleavage sites of tumor necrosis factorα (TNFα), the p75 TNF receptor, the β-amyloid protein precursor, and the c-kit ligand1, implying that it may participate in shedding of these membrane proteins. In fact, ADAM9 has been shown to shed membrane-anchored heparin-binding EGF-like growth factor. In addition, it also cleaves oxidized insulin B-chain and fibronectin. Besides its catalytic activity, ADAM9 functions as an adhesion molelcule through binding of its disintegrin domain to integrins such as αvβ5 and α6β1. The cytoplasmic domain of ADAM9 interacts with Src homology 3 (SH3)containing proteins and protein kinase C, and may mediate different signaling pathways. ADAM9 is widely expressed in tissues.Synonyms: Cellular disintegrin-related protein, Disintegrin and metalloproteinase domain-containing protein 9, KIAA0021, MCMP, MLTNG, Meltrin gamma, Metalloprotease/disintegrin/cysteine-rich protein 9, Myeloma cell metalloproteinase

Gen-ID: 10090

UniProt: Q61072

Pathways: Cellular Response to Molecule of Bacterial Origin, SARS-CoV-2 Protein Interaktom