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CD45RA Antikörper

This anti-CD45RA antibody (ABIN94136) is a Mouse Monoclonal antibody detecting CD45RA in FACS, IHC (p), WB, IP, MS. Suitable for Human.
Produktnummer ABIN94136

Quick Overview for CD45RA Antikörper (ABIN94136)

Target

Alle CD45RA Antikörper anzeigen
CD45RA

Reaktivität

  • 100
  • 9
  • 6
  • 5
  • 2
  • 2
  • 2
  • 1
  • 1
Human

Wirt

  • 116
  • 1
  • 1
Maus

Klonalität

  • 117
  • 1
Monoklonal

Konjugat

  • 30
  • 16
  • 15
  • 7
  • 6
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser CD45RA Antikörper ist unkonjugiert

Applikation

  • 110
  • 28
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  • 26
  • 18
  • 18
  • 15
  • 14
  • 3
  • 3
  • 2
  • 1
  • 1
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Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB), Immunoprecipitation (IP), Mass Spectrometry (MS)

Klon

MEM-56
  • Verwendungszweck

    Anti-Hu CD45RA Purified

    Spezifität

    The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.

    Kreuzreaktivität (Details)

    Human

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Human thymocytes and T lymphocytes.

    Isotyp

    IgG2b
  • Applikationshinweise

    Immunohistochemistry (paraffin sections): No pre-treatment of tissue sections is needed.
    Flow cytometry: Recommended dilution: 0.3-4 μg/mL.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Bazil, Stefanová, Hilgert, Kristofová, Van?k, Bukovský, Horejsí: "Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102." in: Folia biologica, Vol. 35, Issue 5, pp. 289-97, (1990) (PubMed).

  • Target

    CD45RA

    Andere Bezeichnung

    CD45RA

    Hintergrund

    CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naïve T cells and normal plasma cells.,PTPRCR, T200RA
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