NSD1 Antikörper

Produktnummer ABIN932477

Der Maus Monoklonal Anti-NSD1-Antikörper wurde für DB validiert. Er ist geeignet, NSD1 in Proben von Human zu detektieren.

Kurzübersicht für NSD1 Antikörper (ABIN932477)

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NSD1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Klon: 2658C1a

Produktdetails anti-NSD1 Antikörper

Kreuzreaktivität: Human

Kreuzreaktivität (Details): Other species not studied.

Aufreinigung: Protein G affinity chromatography

Immunogen: NSD1 antibody was raised in mouse using recombinant Human Nuclear Receptor Binding Set Domain Protein 1 (Nsd1)

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: NSD1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Details zu NSD1

Target: NSD1 (Nuclear Receptor Binding SET Domain Protein 1 (NSD1))

Andere Bezeichnung: NSD1

Hintergrund: This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98 kDa on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene. Synonyms: Monoclonal NSD1 antibody, Anti-NSD1 antibody, Nuclear receptor binding SET domain protein 1 antibody, STO antibody, KMT3B antibody, SOTOS antibody, ARA267 antibody, FLJ22263 antibody, FLJ44628 antibody, DKFZp666C163 antibody.