GCH1 Antikörper (C-Term)

Produktnummer ABIN929286

Dieses Anti-GCH1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GCH1 in WB. Geeignet für Human.

Kurzübersicht für GCH1 Antikörper (C-Term) (ABIN929286)

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GCH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GCH1 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified

Immunogen: GCH1 antibody was raised in rabbit using the C terminal of GCH1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

GCH1 Blocking Peptide, (ABIN5613736), is also available for use as a blocking control in assays to test for specificity of this GCH1 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu GCH1

Target: GCH1 (GTP Cyclohydrolase 1 (GCH1))

Andere Bezeichnung: GCH1

Hintergrund: This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described, however, not all variants give rise to a functional enzyme. Synonyms: Polyclonal GCH1 antibody, Anti-GCH1 antibody, GTP cyclohydrolase 1 antibody, DYT14 antibody, DYT5 antibody, DYT5a antibody, GCH antibody, GTP-CH-1 antibody, GTPCH1 antibody, HPABH4B antibody.