USP10 Antikörper (C-Term)

Produktnummer ABIN929190

Dieses Anti-USP10-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP10 in WB. Geeignet für Human und Ratte.

Kurzübersicht für USP10 Antikörper (C-Term) (ABIN929190)

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-USP10 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Ratte (Rattus)

Aufreinigung: Purified

Immunogen: Usp10 antibody was raised in rabbit using the C terminal of Usp10 as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

Usp10 Blocking Peptide, catalog no. 33R-7850, is also available for use as a blocking control in assays to test for specificity of this Usp10 antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu USP10

Target: USP10 (Ubiquitin Specific Peptidase 10 (USP10))

Andere Bezeichnung: Usp10

Hintergrund: Usp10 is a hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. It acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Usp10 does not deubiquitinate MDM2 and deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Synonyms: Polyclonal Usp10 antibody, Anti-Usp10 antibody, ubiquitin specific peptidase 10 antibody, MGC124997 antibody.