MDC1 Antikörper (C-Term)

Produktnummer ABIN927646

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MDC1 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für MDC1 Antikörper (C-Term) (ABIN927646)

Target: MDC1 (Mdc1 (MDC1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MDC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MDC1 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified

Immunogen: MDC1 antibody was raised in rabbit using the C terminal of MDC1 as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu MDC1

Target: MDC1 (Mdc1 (MDC1))

Andere Bezeichnung: MDC1

Hintergrund: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Synonyms: Polyclonal MDC1 antibody, Anti-MDC1 antibody, mediator of DNA-damage checkpoint 1 antibody, DKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody.