PML Antikörper (C-Term)

Produktnummer ABIN927422

Der Kaninchen Polyklonal Anti-PML-Antikörper wurde für WB validiert. Er ist geeignet, PML in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für PML Antikörper (C-Term) (ABIN927422)

Target: PML (Promyelocytic Leukemia (PML))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PML Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PML Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Maus, Ratte (Rattus)

Aufreinigung: Purified

Immunogen: PML antibody was raised in rabbit using the C terminal of PML as the immunogen

Anwendungsinformationen

Applikationshinweise: Optimal conditions should be determined by the investigator.

Kommentare:

PML Blocking Peptide, (ABIN937829), is also available for use as a blocking control in assays to test for specificity of this PML antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu PML

Target: PML (Promyelocytic Leukemia (PML))

Andere Bezeichnung: PML

Hintergrund: PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. PML localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions, all variants encode the same N-terminus. Synonyms: Polyclonal PML antibody, Anti-PML antibody, promyelocytic leukemia antibody, MYL antibody, PP8675 antibody, RNF71 antibody, TRIM19 antibody.

Pathways: p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus