PPP4C Antikörper (AA 101-200) (Biotin)

Produktnummer ABIN912031

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PPP4C in WB, ELISA, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für PPP4C Antikörper (AA 101-200) (Biotin) (ABIN912031)

Target: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP4C Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-PPP4C Antikörper (Biotin)

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPP4C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PPP4C

Target: PPP4C (Protein Phosphatase 4, Catalytic Subunit (PPP4C))

Andere Bezeichnung: PPP4C

Hintergrund:

Synonyms: PP X, PP4C, Protein phosphatase X, PP-X, PP4, PP4C, PP4C_HUMAN, PPH3, PPP4, ppp4C, PPX, protein phosphatase 4 formerly X, catalytic subunit, Protein phosphatase 4 catalytic subunit, Protein phosphatase X, protein phosphatase X, catalytic subunit, Serine/threonine protein phosphatase 4 catalytic subunit, Serine/threonine-protein phosphatase 4 catalytic subunit.

Background: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

Gen-ID: 5531