Human Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) Antikörper (Cy5.5)

Produktnummer ABIN901249

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Human Papilloma Virus 33 E7 in IF (cc) und IF (p). Es zeigt Reaktivität gegenüber Proben von Human, Human Papillomavirus (HPV) und Virus.

Kurzübersicht für Human Papilloma Virus 33 E7 (HPV-33 E7) (AA 41-97) Antikörper (Cy5.5) (ABIN901249)

Target: Human Papilloma Virus 33 E7 (HPV-33 E7)

Reaktivität: Human, Human Papillomavirus (HPV), Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Cy5.5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: AA 41-97

Spezifität: This antibody will also detect E7 in HPV58, but with slightly less affinity, due to a one amino acid change in the immunogen sequence range.

Kreuzreaktivität: Human, Virus

Kreuzreaktivität (Details): HPV33

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from HPV33 E7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: Human Papilloma Virus 33 E7 (HPV-33 E7)

Andere Bezeichnung: HPV33 E7

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: E7 protein [Human papillomavirus type 33], Human Papilloma Virus, Human papillomavirus type 33, Human papillomavirus type 33, Protein 33, early protein E7 [Human papillomavirus type 33].

Background: E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription (By similarity).