Glutathione Reductase Antikörper (AA 421-522) (AbBy Fluor® 647)

Produktnummer ABIN899048

Der Kaninchen Polyklonal Anti-Glutathione Reductase-Antikörper wurde für WB, IF (p) und IF (cc) validiert. Er ist geeignet, Glutathione Reductase in Proben von Human und Maus zu detektieren.

Kurzübersicht für Glutathione Reductase Antikörper (AA 421-522) (AbBy Fluor® 647) (ABIN899048)

Target: Glutathione Reductase (GSR)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Reductase Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-Glutathione Reductase Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 421-522

Kreuzreaktivität: Human, Maus

Homologie: Rat,Dog,Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GSR

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Glutathione Reductase

Target: Glutathione Reductase (GSR)

Andere Bezeichnung: GLUR/glutathione reductase

Hintergrund:

Synonyms: glutathione reductase, GLUR, Glutathione reductase mitochondrial, GR, Gr1, GRase, GRD 1, GRD1, GSR, MGC78522.

Background: Glutathione reductase (GR) is a member of pyridine nucleotide- disulfideoxidoreductases, which includes the closely related enzymes thioredoxin reductase, lipoamide dehydrogenase, trypanothione reductase and mercuric ion reductase. GR is a cytoplasmic flavoenzyme widely distributed in aerobic organisms. The dimeric protein is composed of two identical subunits, each containing 1 FAD and 1 redox-active disulfide/dithiol as components of the catalytic apparatus. It plays a role in maintaining glutathione (GSH) in its reduced form by catalyzing the reduction of glutathione disulfide (GSSG): GSSG + NADPH + H+?2GSH + NADP+. In mosteukaryotic cells, GR maintains the ratio of [GSH]/[GSSG], and participates in several vital functions such as the detoxification of reactive oxygen species as well as protein and DNA biosynthesis.

Gen-ID: 2890

Pathways: Thyroid Hormone Synthesis, Cell RedoxHomeostasis