FGA Antikörper (AA 61-160) (AbBy Fluor® 488)

Produktnummer ABIN897205

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FGA in WB, IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Ratte und Maus und wurde in 1 Publikation erwähnt.

Kurzübersicht für FGA Antikörper (AA 61-160) (AbBy Fluor® 488) (ABIN897205)

Target: FGA (Fibrinogen alpha Chain (FGA))

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGA Antikörper ist konjugiert mit AbBy Fluor® 488

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-FGA Antikörper (AbBy Fluor® 488)

Bindungsspezifität: AA 61-160

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Fibrinogen alpha chain

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-FGA Antikörper (AbBy Fluor® 488) (ABIN897205)

Imamura, Yamada, Tsuboi, Nakane, Tsukasaki, Komatsuzaki, Jin: "Near-Infrared Emitting PbS Quantum Dots for in Vivo Fluorescence Imaging of the Thrombotic State in Septic Mouse Brain." in: Molecules (Basel, Switzerland), Vol. 21, Issue 8, (2016) (PubMed).

Details zu FGA

Target: FGA (Fibrinogen alpha Chain (FGA))

Andere Bezeichnung: Fibrinogen alpha chain

Hintergrund:

Synonyms: Fib2, Fibrinogen alpha chain, FGA, Fibrin

Background: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

Gen-ID: 2243

UniProt: P02671