Factor VIII Antikörper (AA 401-500) (AbBy Fluor® 647)

Produktnummer ABIN895962

Dieses Anti-Factor VIII-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Factor VIII in IF (p) und IF (cc). Geeignet für Human, Maus, Ratte und Kaninchen.

Kurzübersicht für Factor VIII Antikörper (AA 401-500) (AbBy Fluor® 647) (ABIN895962)

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reaktivität: Human, Maus, Ratte, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Factor VIII Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-Factor VIII Antikörper (AbBy Fluor® 647)

Bindungsspezifität: AA 401-500

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Dog

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat factor VIII

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Factor VIII

Target: Factor VIII (F8) (Coagulation Factor VIII (F8))

Andere Bezeichnung: Factor 8

Hintergrund:

Synonyms: coagulation factor VIII, Ahf, Antihemophilic factor, Coagulation factor VIII, Coagulation factor VIII procoagulent component, Coagulation factor VIIIc, Dna segment on chromosome x unique 1253 expressed sequence, Dxs1253e, F8, F8 protein,F8c, FactorVIII, FVIII, Hema coagulation factor VIIIc procoagulent component, Hemophilia a, Hemophilia classic,

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].

Molekulargewicht: 267kDa

Gen-ID: 302470

UniProt: Q7TN96