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DEDD2 Antikörper (AA 201-300) (Biotin)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DEDD2 in ELISA, IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Ratte.
Produktnummer ABIN893827

Kurzübersicht für DEDD2 Antikörper (AA 201-300) (Biotin) (ABIN893827)

Target

Alle DEDD2 Antikörper anzeigen
DEDD2 (Death Effector Domain Containing 2 (DEDD2))

Reaktivität

  • 18
  • 17
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Ratte

Wirt

  • 31
Kaninchen

Klonalität

  • 31
Polyklonal

Konjugat

  • 11
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DEDD2 Antikörper ist konjugiert mit Biotin

Applikation

  • 13
  • 13
  • 8
  • 5
  • 2
  • 2
  • 2
  • 1
ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Bindungsspezifität

    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 201-300

    Kreuzreaktivität

    Ratte

    Homologie

    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human DEDD2

    Isotyp

    IgG
  • Applikationshinweise

    IHC-P 1:200-400
    IHC-F 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C for 12 months.

    Haltbarkeit

    12 months
  • Target

    DEDD2 (Death Effector Domain Containing 2 (DEDD2))

    Andere Bezeichnung

    DEDD2

    Hintergrund

    Synonyms: Death effector domain containing 2, DED containing protein FLAME 3, DNA binding death effector domain containing protein 2, FADD like anti apoptotic molecule 3, FLAME 3,

    Background: Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.

    Gen-ID

    162989
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