Corin Antikörper (PE)

Produktnummer ABIN891982

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Corin in IF (p). Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Schwein und Hund.

Kurzübersicht für Corin Antikörper (PE) (ABIN891982)

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reaktivität: Human, Maus, Ratte, Schwein, Hund

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Corin Antikörper ist konjugiert mit PE

Applikation: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Corin Antikörper (PE)

Spezifität: Excitation / Emission Wavelengths: 565nm/578nm

Kreuzreaktivität: Ratte (Rattus), Hund, Schwein

Aufreinigung: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human Corin

Isotyp: IgG

Anwendungsinformationen

Kommentare:

Excitation / Emission wavelength: 496nm / 578nm

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 4 °C for 12 months

Haltbarkeit: 12 months

Details zu Corin

Target: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Andere Bezeichnung: Corin

Hintergrund: Corin was first described as a trypsin-like serine proteinase in the heart which processed pro-atrial natriuretic peptide into the active form ANP. Corin cleaves pro-ANP at Arg98/Ser-99, and blocking Corin message inhibits pro-ANP processing. Null mutant mice lacking Corin develop hypertension, and a series of missense mutations have been identified in humans with high blood pressure and hypertension. Corin is a member of the type-II transmembrane serine proteinases, such as Hepsin, Epitheliasin, Matriptase and enteropeptidase. The Corin domain structure includes a cytoplasmic domain, a transmembrane domain, a spacer region, a frizzled-like domain, 5 LDL Receptor-like domains, another frizzled-like domain, 3 more LDLR-like repeats, a SRCR (Scavenger Receptor-Cysteine Rich) domain (also called macrophage scavenger-like domain), and finally the trypsin-like serine proteinase domain. The complex domain structure puts Corin into the ﾓmosaicﾔ TMPRSS family, so named because of the wide variety of domains.

Molekulargewicht: 117kDa

Gen-ID: 10699

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones