Caveolin 2 Antikörper (AbBy Fluor® 647)

Produktnummer ABIN886835

Der Kaninchen Polyklonal anti-Caveolin 2 Antikörper wird verwendet zum Nachweis von Caveolin 2 in Proben von Human. Er wurde validiert für IF.

Kurzübersicht für Caveolin 2 Antikörper (AbBy Fluor® 647) (ABIN886835)

Target: Caveolin 2 (CAV2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Caveolin 2 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (IF)

Produktdetails anti-Caveolin 2 Antikörper (AbBy Fluor® 647)

Verwendungszweck: Caveolin-2 Polyclonal Antibody, AbBy Fluor-647 Conjugated

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Caveolin-2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IF=1:100-500)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Caveolin 2

Target: Caveolin 2 (CAV2)

Andere Bezeichnung: Caveolin-2

Hintergrund:

Synonyms: CAV, CAV2, CAV2_HUMAN, Caveolae protein 20 kD, Caveolin 2, Caveolin2, Caveolin 2 isoform a and b, Caveolin 2 isoform c, Caveolin-2, MGC12294.

Background: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.

Gen-ID: 858

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development