e4EBP1,2,3 (pThr45) Antikörper (AbBy Fluor® 350)

Produktnummer ABIN878105

Der Kaninchen Polyklonal Anti--Antikörper wurde für WB, IF (cc) und IF (p) validiert. Er ist geeignet, in Proben von Human zu detektieren.

Kurzübersicht für e4EBP1,2,3 (pThr45) Antikörper (AbBy Fluor® 350) (ABIN878105)

Target: e4EBP1,2,3

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: pThr45

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Guinea Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human eIF4EBP1 around the phosphorylation site of Thr45

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: e4EBP1,2,3

Andere Bezeichnung: e4EBP1+2+3

Hintergrund:

Synonyms: p-4E-BP1/2/3 Thr 45, p-4EBP1/2/3Thr 45, e4EBP1 phospho T36, e4EBP1 phospho Thr36, p-e4EBP1 Thr36, e4EBP1, Eukaryotic translation initiation factor 4E binding protein 1, Eukaryotic translation initiation factor 4E-binding protein 1, 4E BP1, 4EBP1, BP 1, BP1, e4E binding protein 1, e4E-binding protein 1, Eukaryotic translation initiation factor 4E binding protein 1, MGC4316, PHAS I, PHASI, PHAS-I, PHAS, 4E-BP1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, Phosphorylated heat and acid stable protein regulated by insulin 1, 4EBP1_HUMAN.

Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].

Gen-ID: 1978