DAXX Antikörper (pSer495) (AbBy Fluor® 350)

Produktnummer ABIN876387

Dieses Anti-DAXX-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DAXX in WB, IF (p) und IF (cc). Geeignet für Human und Ratte.

Kurzübersicht für DAXX Antikörper (pSer495) (AbBy Fluor® 350) (ABIN876387)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DAXX Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Produktdetails anti-DAXX Antikörper (AbBy Fluor® 350)

Bindungsspezifität: pSer495

Spezifität: This phosphorylation site is homologous to that of Ser505 in Bovine.

Kreuzreaktivität: Human, Ratte

Homologie: Cow,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human DAXX around the phosphorylation site of Ser495

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Andere Bezeichnung: DAXX

Hintergrund:

Synonyms: DAP6, EAP1, BING2, Death domain-associated protein 6, Daxx, hDaxx, ETS1-associated protein 1, Fas death domain-associated protein

Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gen-ID: 1616

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway