Histone 3 Antikörper (3meLys37) (AbBy Fluor® 647)

Produktnummer ABIN873727

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Histone 3 in WB, FACS, IF (cc) und IF (p). Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für Histone 3 Antikörper (3meLys37) (AbBy Fluor® 647) (ABIN873727)

Target: Histone 3 (H3) (Histone H3 (H3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Histone 3 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Histone 3 Antikörper (AbBy Fluor® 647)

Bindungsspezifität: 3meLys37

Kreuzreaktivität: Human, Maus

Homologie: Rat,Cow,Pig,Rabbit,Drosophila

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic metylpeptide derived from human Histone H3 around metylation site of K37

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Histone 3

Target: Histone 3 (H3) (Histone H3 (H3))

Andere Bezeichnung: Histone H3

Hintergrund:

Synonyms: Histone H3Tri Methyl K37, Tri methyl Histone H3K37, H3F3, HIST3H3, Histone H3 3 pseudogene, H31_TETTH, Histone H3, H3S, Histone H3-I/H3-II, Major histone H3, H3F, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l.

Background: Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15 and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis.

Gen-ID: 3020