HNE Antikörper

Produktnummer ABIN873270

Dieser Anti-HNE Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von HNE in WB, ELISA, IF (p), IHC (fro) und IHC (p). Geeignet für . Dieses Primary Antibody wurde in 13+ Publikationen zitiert.

Kurzübersicht für HNE Antikörper (ABIN873270)

Target: HNE (4-Hydroxynonenal (HNE))

Reaktivität: Bitte anfragen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HNE Antikörper

Kreuzreaktivität: Affe, Maus, Ratte

Kreuzreaktivität (Details): 4-Hydroxynonenal

Aufreinigung: Purified by Protein A.

Immunogen: 4 Hydroxynonenal conjugated to BSA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:100-500
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-HNE Antikörper (ABIN873270)

Shin, Lee, Jang, Kim, Park, Kang, Shim, Ko, Hwang: "Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cells." in: Scientific reports, Vol. 15, Issue 1, pp. 44014, (2025) (PubMed).

Zhang, Chang, Chen, Beg, Huang, Vick, Wang, Zhang, Yttre, Gupta, Castleberry, Zhang, Dai, Zhu, Song, Yang, Brown, Xu, Ma, Smith, Zielonka, Traylor, Ben Dhaou, Orr, Cui, Chen: "Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis." in: Journal of lipid research, Vol. 66, Issue 5, pp. 100809, (2025) (PubMed).

Târtea, Popa-Wagner, Sfredel, Mitran, Dan, Țucă, Preda, Raicea, Țieranu, Cozma, Vătășescu: "Chitosan Versus Dapagliflozin in a Diabetic Cardiomyopathy Mouse Model." in: International journal of molecular sciences, Vol. 25, Issue 4, (2024) (PubMed).

Zhang, Chang, Chen, Beg, Huang, Vick, Wang, Zhang, Yttre, Gupta, Castleberry, Zhang, Dai, Song, Zhu, Yang, Brown, Xu, Ma, Smith, Zielonka, Traylor, Dhaou, Orr, Cui, Zheng, Chen: "Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway." in: bioRxiv : the preprint server for biology, (2024) (PubMed).

Chien, Wen, Cheng, Tsai, Chiang, Chien: "Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).

Vairappan, Sundhar, Srinivas: "Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl4-Induced Cirrhotic Mice." in: Molecular neurobiology, Vol. 56, Issue 7, pp. 4718-4729, (2019) (PubMed).

Sapkota, Gaire, Cho, Jeon, Kwon, Jang, Kim, Ryu, Choi: "Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation." in: PLoS ONE, Vol. 12, Issue 2, pp. e0171479, (2017) (PubMed).

Kagaya, Sasaki, Kino, Taniguchi, Kuraishi, Andoh: "Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion." in: Neuroscience letters, Vol. 631, pp. 109-14, (2016) (PubMed).

Zhang, Song, Pang, Zhang, Wan, Yuan, Wu, Liu: "Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice." in: World journal of gastroenterology : WJG, Vol. 21, Issue 14, pp. 4195-209, (2015) (PubMed).

Polverino, Doyle-Eisele, McDonald, Wilder, Royer, Laucho-Contreras, Kelly, Divo, Pinto-Plata, Mauderly, Celli, Tesfaigzi, Owen: "A novel nonhuman primate model of cigarette smoke-induced airway disease." in: The American journal of pathology, Vol. 185, Issue 3, pp. 741-55, (2015) (PubMed).

Duong, Chami, McMahon, Fong, Dennis, Freedman, Witting: "Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury." in: Journal of neurochemistry, Vol. 130, Issue 6, pp. 733-47, (2014) (PubMed).

Haberman, Tickle, Dexheimer, Kim, Tang, Karns, Baldassano, Noe, Rosh, Markowitz, Heyman, Griffiths, Crandall, Mack, Baker, Huttenhower, Keljo, Hyams, Kugathasan, Walters, Aronow, Xavier, Gevers et al.: "Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. ..." in: The Journal of clinical investigation, Vol. 124, Issue 8, pp. 3617-33, (2014) (PubMed).

Guo, Tong, Xi, Yang, Dong, Wen: "Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats." in: Journal of ethnopharmacology, Vol. 144, Issue 3, pp. 768-74, (2012) (PubMed).

Details zu HNE

Target: HNE (4-Hydroxynonenal (HNE))

Andere Bezeichnung: 4 Hydroxynonenal

Substanzklasse: Chemical

Hintergrund:

Synonyms: 4-Hydroxy-2-Nonenal, 4Hydroxynonenal, 4-Hydroxynonenal, 4 HNE, 4HNE, 4-HNE, E-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA.

Background: Aldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress 4-HNE has been hypothesized to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.