HNE Antikörper

Produktnummer ABIN873270

Dieses Anti-HNE-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von HNE in WB, ELISA, IF (p), IHC (fro) und IHC (p). Geeignet für . Dieses Primary Antibody wurde in 10+ Publikationen zitiert.

Kurzübersicht für HNE Antikörper (ABIN873270)

Target: HNE (4-Hydroxynonenal (HNE))

Reaktivität: Bitte anfragen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HNE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HNE Antikörper

Kreuzreaktivität: Affe, Maus, Ratte

Kreuzreaktivität (Details): 4-Hydroxynonenal

Aufreinigung: Purified by Protein A.

Immunogen: 4 Hydroxynonenal conjugated to BSA

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:100-500
IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-HNE Antikörper (ABIN873270)

Zhang, Chang, Chen, Beg, Huang, Vick, Wang, Zhang, Yttre, Gupta, Castleberry, Zhang, Dai, Song, Zhu, Yang, Brown, Xu, Ma, Smith, Zielonka, Traylor, Dhaou, Orr, Cui, Zheng, Chen: "Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway." in: bioRxiv : the preprint server for biology, (2024) (PubMed).

Chien, Wen, Cheng, Tsai, Chiang, Chien: "Diabetes Upregulates Oxidative Stress and Downregulates Cardiac Protection to Exacerbate Myocardial Ischemia/Reperfusion Injury in Rats." in: Antioxidants (Basel, Switzerland), Vol. 9, Issue 8, (2020) (PubMed).

Vairappan, Sundhar, Srinivas: "Resveratrol Restores Neuronal Tight Junction Proteins Through Correction of Ammonia and Inflammation in CCl4-Induced Cirrhotic Mice." in: Molecular neurobiology, Vol. 56, Issue 7, pp. 4718-4729, (2019) (PubMed).

Sapkota, Gaire, Cho, Jeon, Kwon, Jang, Kim, Ryu, Choi: "Eupatilin exerts neuroprotective effects in mice with transient focal cerebral ischemia by reducing microglial activation." in: PLoS ONE, Vol. 12, Issue 2, pp. e0171479, (2017) (PubMed).

Kagaya, Sasaki, Kino, Taniguchi, Kuraishi, Andoh: "Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion." in: Neuroscience letters, Vol. 631, pp. 109-14, (2016) (PubMed).

Zhang, Song, Pang, Zhang, Wan, Yuan, Wu, Liu: "Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice." in: World journal of gastroenterology : WJG, Vol. 21, Issue 14, pp. 4195-209, (2015) (PubMed).

Polverino, Doyle-Eisele, McDonald, Wilder, Royer, Laucho-Contreras, Kelly, Divo, Pinto-Plata, Mauderly, Celli, Tesfaigzi, Owen: "A novel nonhuman primate model of cigarette smoke-induced airway disease." in: The American journal of pathology, Vol. 185, Issue 3, pp. 741-55, (2015) (PubMed).

Duong, Chami, McMahon, Fong, Dennis, Freedman, Witting: "Pre-treatment with the synthetic antioxidant T-butyl bisphenol protects cerebral tissues from experimental ischemia reperfusion injury." in: Journal of neurochemistry, Vol. 130, Issue 6, pp. 733-47, (2014) (PubMed).

Haberman, Tickle, Dexheimer, Kim, Tang, Karns, Baldassano, Noe, Rosh, Markowitz, Heyman, Griffiths, Crandall, Mack, Baker, Huttenhower, Keljo, Hyams, Kugathasan, Walters, Aronow, Xavier, Gevers et al.: "Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. ..." in: The Journal of clinical investigation, Vol. 124, Issue 8, pp. 3617-33, (2014) (PubMed).

Guo, Tong, Xi, Yang, Dong, Wen: "Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats." in: Journal of ethnopharmacology, Vol. 144, Issue 3, pp. 768-74, (2012) (PubMed).

Details zu HNE

Target: HNE (4-Hydroxynonenal (HNE))

Andere Bezeichnung: 4 Hydroxynonenal

Substanzklasse: Chemical

Hintergrund:

Synonyms: 4-Hydroxy-2-Nonenal, 4Hydroxynonenal, 4-Hydroxynonenal, 4 HNE, 4HNE, 4-HNE, E-4-Hydroxynonenal-dimethylacetal, 4-HNE-DMA.

Background: Aldehydic products of lipid peroxidation, such as 4 hydroxynonenal (4 HNE), have been implicated in the etiology of pathological changes under oxidative stress as a key mediator of oxidative stress induced cell death. It is a stable product of lipid peroxidation, is proarrhythmic and may contribute to the cytotoxic effects of oxidative stress 4-HNE has been hypothesized to play a key role in cell signal transduction, in a variety of pathways from cell cycle events to cellular adhesion.