ARRDC3 Antikörper (AA 178-215)

Produktnummer ABIN872868

Produktdetails anti-ARRDC3 Antikörper

Target: ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))

Bindungsspezifität: AA 178-215

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARRDC3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARRDC3 corresponding to amino acids 178-215.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ARRDC3

Target: ARRDC3 (Arrestin Domain Containing 3 (ARRDC3))

Andere Bezeichnung: ARRDC3 (ARRDC3 Produkte)

Synonyme: TLIMP antikoerper, AI450344 antikoerper, mKIAA1376 antikoerper, LRRGT00048 antikoerper, ARRDC3 antikoerper, arrdc3 antikoerper, si:dkey-172m14.3 antikoerper, wu:fc21e01 antikoerper, zgc:136956 antikoerper, MGC131006 antikoerper, DKFZp469D0714 antikoerper, zgc:92034 antikoerper, arrestin domain containing 3 antikoerper, arrestin domain containing 3a antikoerper, arrestin domain containing 3 S homeolog antikoerper, arrestin domain containing 3b antikoerper, ARRDC3 antikoerper, Arrdc3 antikoerper, arrdc3 antikoerper, arrdc3a antikoerper, arrdc3.S antikoerper, arrdc3b antikoerper

Hintergrund:

Synonyms: ARRDC 3, Arrestin domain containing protein 3, KIAA1376, Thioredoxin binding protein 2 like inducible membrane, TLIMP, ARRD3_HUMAN.

Background: The arrestins are a family of proteins that are important for regulating signal transduction within cells. Arrestins are part of a conserved two step mechanism for regulating the activity of G-protein coupled receptors (GPCRs). In response to a stimulus, GPCRs activate a heterotrimeric G protein. In order to turn off this response, or adapt to a constant stimulus, activated receptors need to be silenced. The first step is phosphorylation by a class of serine/threonine kinases called G protein coupled receptor kinases (GRKs). This phosphorylation specifically marks the activated receptor for arrestin binding. Once arrestin is bound to the receptor it is unable to signal further. Recent research continues to expand the known actions of arrestins, which can bind to other classes of receptors and can directly activate signaling pathways on their own. Different arrestins (visual arrestin (or Arrestin 1), beta-arrestin 1 (or Arrestin 2) and beta-arrestin 2 (or Arrestin 3) can reduce the activity of their target GPCRs in several different ways.

Gen-ID: 57561