Caveolin 2 Antikörper
Kurzübersicht für Caveolin 2 Antikörper (ABIN872473)
Target
Alle Caveolin 2 (CAV2) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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                                            Aufreinigung
- Purified by Protein A.
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                                            Immunogen
- KLH conjugated synthetic peptide derived from human Caveolin-2
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                                            Isotyp
- IgG
 
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                                            Applikationshinweise
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                        WB 1:100-1000
 IHC-P 1:100-500
 IF(IHC-P) 1:50-200
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                                            Beschränkungen
- Nur für Forschungszwecke einsetzbar
 
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                                            Format
- Liquid
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                                            Konzentration
- 1 μg/μL
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                                            Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
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                                            Konservierungsmittel
- Sodium azide
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                                            Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            Lagerung
- -20 °C
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                                            Informationen zur Lagerung
- Store at -20°C
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                                            Haltbarkeit
- 12 months
 
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    - Caveolin 2 (CAV2)
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                                            Andere Bezeichnung
- Caveolin-2
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                                            Hintergrund
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                        May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression.Tissue specificity: Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.Cellular localization: Nucleus. Cytoplasm. Golgi apparatus membrane. Cell membrane. Membrane > caveola. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments. Synonyms: CAV, CAV2, CAV2_HUMAN, Caveolae protein 20 kD, Caveolin 2, Caveolin2, Caveolin 2 isoform a and b, Caveolin 2 isoform c, Caveolin-2, MGC12294. 
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                                            Gen-ID
- 858
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                                            Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Skeletal Muscle Fiber Development
 Target
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