CEMIP Antikörper (AA 101-200)

Produktnummer ABIN872432

Der Kaninchen Polyklonal Anti-CEMIP-Antikörper wurde für WB, ELISA, IF (cc), IF (p), IHC (fro) und IHC (p) validiert. Er ist geeignet, CEMIP in Proben von Human, Maus und Ratte zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für CEMIP Antikörper (AA 101-200) (ABIN872432)

Target: CEMIP (Cell Migration Inducing Hyaluronan Binding Protein (CEMIP))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEMIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-CEMIP Antikörper

Bindungsspezifität: AA 101-200

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMEM2L

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-CEMIP Antikörper (ABIN872432)

Liang, Fang, Yang, Song: "Silencing of CEMIP suppresses Wnt/β-catenin/Snail signaling transduction and inhibits EMT program of colorectal cancer cells." in: Acta histochemica, Vol. 120, Issue 1, pp. 56-63, (2017) (PubMed).

Details zu CEMIP

Target: CEMIP (Cell Migration Inducing Hyaluronan Binding Protein (CEMIP))

Andere Bezeichnung: CEMIP

Hintergrund:

Synonyms: CCSP1, TMEM2L, KIAA1199, Cell migration-inducing and hyaluronan-binding protein, CEMIP, HYBID

Background: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Gen-ID: 57214

UniProt: Q8WUJ3