CRTC2 Antikörper

Produktnummer ABIN865510

Dieser Maus Monoklonal Antikörper detektiert spezifisch CRTC2 in WB, ELISA, IHC, IF und FACS. Es zeigt Reaktivität gegenüber Proben von Human und Affe.

Kurzübersicht für CRTC2 Antikörper (ABIN865510)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRTC2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 5B10

Produktdetails anti-CRTC2 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human CRTC2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB:1/500 - 1/2000,IHC:1/200 - 1/1000,IF:1/200-1/1000,FC:1/200-1/400, ELISA: Propose dilution 1/10000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Andere Bezeichnung: CRTC2

Hintergrund: Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic -cells through a glucose sensing pathway. Feeding also stimulates release of gut hormones such as glucagon-like peptide-1 (GLP-1), which further induces insulin release, inhibits glucagon release and promotes -cell viability. CREB-dependent transcription likely plays a role in both glucose sensing and GLP-1 signaling . The protein Torc2 (transducer of regulated CREB activity 2) functions as a CREB co-activator and is implicated in mediating the effects of these two pathways . In quiescent cells, Torc2 is phosphorylated at Ser171 and becomes sequestered in the cytoplasm via an interaction with 14-3-3 proteins. Glucose and gut hormones lead to the dephosphorylation of Torc2 and its dissociation from 14-3-3 proteins. Dephosphorylated Torc2 enters the nucleus to promote CREB-dependent transcription. Synonyms: TORC2, TORC-2, CRTC2

Molekulargewicht: 80kDa

Gen-ID: 200186

Pathways: AMPK Signaling, Carbohydrate Homeostasis