SNAIL Antikörper

Produktnummer ABIN865486

Dieser Maus Monoklonal Antikörper detektiert spezifisch SNAIL in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SNAIL Antikörper (ABIN865486)

Target: SNAIL (SNAI1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 6D2

Produktdetails anti-SNAIL Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1/500 - 1/2000, ELISA: Propose dilution 1/10000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu SNAIL

Target: SNAIL (SNAI1)

Andere Bezeichnung: SNAI1

Hintergrund: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function . Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney. Synonyms: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Molekulargewicht: 29kDa

Gen-ID: 6615

Pathways: Negative Regulation of intrinsic apoptotic Signaling