DUX4 Antikörper (C-Term)

Produktnummer ABIN863109

Dieses Anti-DUX4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von DUX4 in WB, IHC, IF und ICC. Geeignet für Human.

Kurzübersicht für DUX4 Antikörper (C-Term) (ABIN863109)

Target: DUX4 (Double Homeobox 4 (DUX4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DUX4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Klon: P2B1

Produktdetails anti-DUX4 Antikörper

Bindungsspezifität: C-Term

Spezifität: Detects ~45 kDa. No cross-reactivity with DUX4c.

Kreuzreaktivität: Human, Maus

Aufreinigung: Protein G Purified

Immunogen: C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:1000)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN863109 was sufficient for detection of DUX4 in 20 μg of HeLa cell lysate by ECL immunoblot analysis using goat anti-mouse IgG: HRP as teh secondary.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C

Details zu DUX4

Target: DUX4 (Double Homeobox 4 (DUX4))

Andere Bezeichnung: DUX4

Hintergrund: DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).

Gen-ID: 22947

NCBI Accession: NP_149418

UniProt: F5GZ66