GRIN2B Antikörper (pSer1480)

Produktnummer ABIN801243

Dieses Anti-GRIN2B-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRIN2B in WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro). Geeignet für Human, Ratte und Maus. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für GRIN2B Antikörper (pSer1480) (ABIN801243)

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GRIN2B Antikörper

Bindungsspezifität: pSer1480

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from mouse NMDAR2B around the phosphorylation site of Ser1480

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-GRIN2B Antikörper (ABIN801243)

Wen, Fu, Wu, Si, Xie, Dan, Zhan, Shi: "Inhibition of Calcineurin A by FK506 Suppresses Seizures and Reduces the Expression of GluN2B in Membrane Fraction." in: Neurochemical research, (2017) (PubMed).

Details zu GRIN2B

Target: GRIN2B (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B (GRIN2B))

Andere Bezeichnung: NMDAR2B

Hintergrund:

Synonyms: NMDAR2B Tyr1480, NMDAR2B Y1480, p-NMDAR2B Tyr1480, p-NMDAR2B Y1480, AW490526, Glutamate [NMDA] receptor subunit epsilon 2, Glutamate [NMDA] receptor subunit epsilon-2, Glutamate Receptor Ionotropic N Methyl D Aspartate 2B, Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B, Glutamate receptor ionotropic NMDA2B, Glutamate receptor subunit epsilon 2, Glutamate receptor, ionotropic, NMDA2B epsilon 2, GRIN 2B, GRIN2B, hNR 3, hNR3, MGC142178, MGC142180, N methyl D asparate receptor channel subunit epsilon 2, N METHYL D ASPARTATE RECEPTOR CHANNEL SUBUNIT EPSILON 2, N methyl D aspartate receptor subtype 2B, N methyl D aspartate receptor subunit 2B, N methyl D aspartate receptor subunit 3, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, NMDA NR2B, NMDA R2B, Nmdar2b, NMDE2, NMDE2_HUMAN, NME2, NR2B, NR3.

Background: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].

Gen-ID: 2904

Pathways: Response to Growth Hormone Stimulus, Synaptic Membrane, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity