GAP43 Antikörper (AA 216-226)

Produktnummer ABIN789021

Dieses Anti-GAP43-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GAP43 in WB, IHC und FACS. Geeignet für Human, Ratte, Maus und Huhn.

Kurzübersicht für GAP43 Antikörper (AA 216-226) (ABIN789021)

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Reaktivität: Human, Ratte, Maus, Huhn

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GAP43 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Produktdetails anti-GAP43 Antikörper

Bindungsspezifität: AA 216-226

Kreuzreaktivität: Huhn, Human, Maus, Ratte (Rattus)

Aufreinigung: affinity purified

Immunogen: Synthetic peptide corresponding to AA 216-226 of rat/mouse GAP-43, (C)-KEDPEADQEHA coupled to maleimide-activated KLH.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu GAP43

Target: GAP43 (Growth Associated Protein 43 (GAP43))

Andere Bezeichnung: GAP43

Hintergrund: GAP-43 (growth associated protein 43 kDa, also known as neuromodulin) is a 24 kDa, neuron growth cone-associated member of the neuromodulin family. Apparently due to its tertiary structure, it runs anomalously at 43 kDa on SDS-polyacrylamide gel. Rat GAP-43 is a 226 amino acid (aa) protein that contains an N-terminal lipid binding motif, an 11 aa IQ domain (IQ:Ile-Gln-X-Ser-etc) (aa 38 - 48), and a C-terminus with four potential serine phosphorylation sites. The molecule may utilize the IQ domain to bind calmodulin. Protein kinase C-mediated phosphorylation of the Serine at 41 within this site inhibits this interaction. Unphosphorylated, calmodulin-bound GAP-43 is always associated with neurite retraction, while S41 phosphorylated GAP-43 stabilizes actin filaments and promotes growth cone extension.