GRIN2C Antikörper (pSer1244)

Produktnummer ABIN784608

Dieses Anti-GRIN2C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GRIN2C in WB. Geeignet für Human, Maus, Ratte, Rind (Kuh), Hund und Non-Human Primate.

Kurzübersicht für GRIN2C Antikörper (pSer1244) (ABIN784608)

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Non-Human Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRIN2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GRIN2C Antikörper

Bindungsspezifität: pSer1244

Spezifität: Specific for the ~140k NR2C subunit of the NMDA receptor phosphorylated at Ser1244. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide that was used to generate the antibody but not by the corresponding dephospho-peptide.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine, Human and non-Human primates.
Species reactivity (tested):Mouse and Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Synthetic phospho-peptide surrounding the phospho Ser1244 of the NR2C-subunit of Rat NMDA receptor.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted (in aliquots) at -20 °C.

Details zu GRIN2C

Target: GRIN2C (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2c (GRIN2C))

Andere Bezeichnung: NMDA Receptor 2C

Hintergrund: The ion channels activated by glutamate that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002, Wenthold et al., 2003, Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989, Alvestad et al., 2003, Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The NR2C subunit of the receptor is thought to influence the NMDAR conductance level (Ebralidze et al., 1996). Phosphorylation of Ser1244 has been shown to regulate NMDA receptor channel function (Chen et al., 2006).Synonyms: GRIN2C, Glutamate [NMDA] receptor subunit epsilon-3, N-methyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C

Gen-ID: 24411

NCBI Accession: NP_036707

Pathways: Synaptic Membrane