GRM7 Antikörper (pSer862)

Produktnummer ABIN784604

Der Kaninchen Polyklonal Anti-GRM7-Antikörper wurde für IHC (fro) validiert. Er ist geeignet, GRM7 in Proben von Human, Ratte, Maus, Hund, Rind (Kuh), Zebrafisch (Danio rerio) und Non-Human Primate zu detektieren.

Kurzübersicht für GRM7 Antikörper (pSer862) (ABIN784604)

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Reaktivität: Human, Ratte, Maus, Hund, Rind (Kuh), Zebrafisch (Danio rerio), Non-Human Primate

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM7 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-GRM7 Antikörper

Bindungsspezifität: pSer862

Spezifität: Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.

Kreuzreaktivität (Details): Species reactivity (expected):Bovine, Canine, Human, non-Human Primate and Zebrafish.
Species reactivity (tested):Mouse and Rat.

Aufreinigung: Affinity Chromatography.

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding phospho-Ser862 of Rat mGluR7.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Handhabung: Avoid repeated freezing and thawing.

Details zu GRM7

Target: GRM7 (Glutamate Receptor, Metabotropic 7 (GRM7))

Andere Bezeichnung: mGluR7 / GRM7

Hintergrund: Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004, Francesconi et al., 2004, Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).Synonyms: GPRC1G, MGLUR7, Metabotropic glutamate receptor 7

Gen-ID: 81672

NCBI Accession: NP_112302

Pathways: Sensory Perception of Sound, cAMP Metabolic Process, Feeding Behaviour