ZEB2 Antikörper (C-Term)

Produktnummer ABIN784073

Der Kaninchen Polyklonal Anti-ZEB2-Antikörper wurde für WB, IF, IHC (p) und EIA validiert. Er ist geeignet, ZEB2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ZEB2 Antikörper (C-Term) (ABIN784073)

Target: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZEB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ZEB2 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to the C-term of ZEB2.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: ZEB2 antibody was raised against an 18 amino acid synthetic near the carboxy terminus of Human ZEB2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ZEB2

Target: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Andere Bezeichnung: ZFHX1B

Hintergrund: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.Synonyms: KIAA0569, SIP1, SMADIP1, Smad-interacting protein 1, ZEB2, ZFX1B, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox protein 1b

Gen-ID: 9839

NCBI Accession: NP_001165124

Pathways: Tube Formation