ERP44 Antikörper (Internal Region)

Produktnummer ABIN784030

Produktdetails anti-ERP44 Antikörper

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERP44 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody reacts to the internal region of ERP44 / TXNDC4.

Aufreinigung: Immunoaffinity chromatography

Immunogen: ERP44 antibody was raised against internal domain of human.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ERP44

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Andere Bezeichnung: TXNDC4 / ERP44 (ERP44 Produkte)

Synonyme: PDIA10 antikoerper, TXNDC4 antikoerper, 1110001E24Rik antikoerper, AI849526 antikoerper, AL033348 antikoerper, Txndc4 antikoerper, BWK4 antikoerper, txndc4 antikoerper, zgc:77883 antikoerper, endoplasmic reticulum protein 44 antikoerper, ERP44 antikoerper, Erp44 antikoerper, erp44 antikoerper

Hintergrund: TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4

Gen-ID: 23071

NCBI Accession: NP_055866

Pathways: Cell RedoxHomeostasis, SARS-CoV-2 Protein Interaktom