ERP44 Antikörper (Internal Region)

Produktnummer ABIN784030

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ERP44 in IHC (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für ERP44 Antikörper (Internal Region) (ABIN784030)

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ERP44 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-ERP44 Antikörper

Bindungsspezifität: Internal Region

Spezifität: This antibody reacts to the internal region of ERP44 / TXNDC4.

Aufreinigung: Immunoaffinity chromatography

Immunogen: ERP44 antibody was raised against internal domain of human.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS containing 0.09 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ERP44

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Andere Bezeichnung: TXNDC4 / ERP44

Hintergrund: TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides with both hEROs and cargo folding intermediates. Over expression has been shown to alter the equilibrium of the different Ero1-Lalpha redox isoforms suggesting that TXNDC4 may be involved in the control of oxidative protein folding. It has also been suggested that TXNDC4 senses the environment in the ER lumen because it modulates IP3R1 (1,4,5-triphosphate receptor type 1) activity thereby regulating cytosolic calcium concentrations and intraluminal conditions.Synonyms: Endoplasmic reticulum resident protein ERp44, KIAA0573, Thioredoxin domain-containing protein 4

Gen-ID: 23071

NCBI Accession: NP_055866

Pathways: Cell RedoxHomeostasis, SARS-CoV-2 Protein Interaktom