PKDCC Antikörper (Center)

Produktnummer ABIN783833

Es sind 2+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-PKDCC Antikörper wird verwendet zum Nachweis von PKDCC in Proben von Human, Maus und Ratte. Er wurde validiert für WB und EIA.

Kurzübersicht für PKDCC Antikörper (Center) (ABIN783833)

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKDCC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-PKDCC Antikörper

Bindungsspezifität: Center

Aufreinigung: Affinity chromatography

Immunogen: 15 amino acid peptide from near the center of human VLK.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Referenzen für anti-PKDCC Antikörper (ABIN783833)

Maddala, Skiba, Rao: "Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells." in: Journal of cellular physiology, Vol. 232, Issue 9, pp. 2447-2460, (2017) (PubMed).

Bordoli, Yum, Breitkopf, Thon, Italiano, Xiao, Worby, Wong, Lin, Edenius, Keller, Asara, Dixon, Yeo, Whitman: "A secreted tyrosine kinase acts in the extracellular environment." in: Cell, Vol. 158, Issue 5, pp. 1033-44, (2014) (PubMed).

Details zu PKDCC

Target: PKDCC (Protein Kinase Domain Containing, Cytoplasmic Homolog (Mouse) (PKDCC))

Andere Bezeichnung: PKDCC

Hintergrund: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.Synonyms: LOC91461, Protein kinase domain-containing protein, Protein kinase-like protein SgK493, Sugen kinase 493, VLK, Vertebrate lonesome kinase

Gen-ID: 91461

NCBI Accession: NP_612379

UniProt: Q504Y2