RWDD3 Antikörper (N-Term)

Produktnummer ABIN783831

Produktdetails anti-RWDD3 Antikörper

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RWDD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to RWD domain containing 3.

Aufreinigung: Affinity chromatography

Immunogen: 17 amino acid peptide from near the amino terminus of human RWDD3.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu RWDD3

Target: RWDD3 (RWD Domain Containing 3 (RWDD3))

Andere Bezeichnung: RWDD3 (RWDD3 Produkte)

Synonyme: DKFZp469N1913 antikoerper, RSUME antikoerper, 2510027J23Rik antikoerper, 3110037C01Rik antikoerper, AI035684 antikoerper, AI662458 antikoerper, X2CR1 antikoerper, X2cr1 antikoerper, zgc:73229 antikoerper, RWD domain containing 3 antikoerper, RWDD3 antikoerper, rwdd3 antikoerper, Rwdd3 antikoerper

Hintergrund: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.Synonyms: RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer

Gen-ID: 25950

NCBI Accession: NP_001121614

UniProt: Q9Y3V2