ZBP1 Antikörper (C-Term)

Produktnummer ABIN783819

Dieses Anti-ZBP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ZBP1 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ZBP1 Antikörper (C-Term) (ABIN783819)

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ZBP1 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to ZBP1.

Aufreinigung: Affinity chromatography

Immunogen: 18 amino acid peptide from near the carboxy terminus of human ZBP1.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ZBP1

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Andere Bezeichnung: ZBP1

Hintergrund: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.Synonyms: C20orf183, DLM1, Z-DNA-binding protein 1

Gen-ID: 81030

NCBI Accession: NP_001153889

UniProt: Q9H171