CXXC4 Antikörper (N-Term)
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- Target Alle CXXC4 Antikörper anzeigen
- CXXC4 (CXXC Finger Protein 4 (CXXC4))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CXXC4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Spezifität
- This antibody detects CXXC4 at N-term.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, mouse, rat
- Aufreinigung
- Affinity chromatography purified via peptide column
- Immunogen
- 18 amino acid peptide near the amino terminus of human CXXC4
- Top Product
- Discover our top product CXXC4 Primärantikörper
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS containing 0.02 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- Target
- CXXC4 (CXXC Finger Protein 4 (CXXC4))
- Andere Bezeichnung
- CXXC4 (CXXC4 Produkte)
- Synonyme
- 9330210J02Rik antikoerper, C030003J12Rik antikoerper, Idax antikoerper, IDAX antikoerper, Xldax antikoerper, xIdax antikoerper, CXXC finger 4 antikoerper, CXXC finger protein 4 antikoerper, CXXC finger protein 4 S homeolog antikoerper, Cxxc4 antikoerper, CXXC4 antikoerper, cxxc4.S antikoerper
- Hintergrund
- CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.Synonyms: CXXC-type zinc finger protein 4, IDAX, Inhibition of the Dvl and axin complex protein
- Gen-ID
- 80319
- NCBI Accession
- NP_079488
- UniProt
- Q9H2H0
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