TCTN1 Antikörper (N-Term)

Produktnummer ABIN783637

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TCTN1 in WB, IF und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für TCTN1 Antikörper (N-Term) (ABIN783637)

Target: TCTN1 (Tectonic Family Member 1 (TCTN1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCTN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-TCTN1 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects TCTN1 . It is predicted to not cross-react with other TCTN members. Multiple isoforms are known to exist, this antibody recognizes isoforms 1 - 3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Mouse

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the amino terminus of human TCTN1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TCTN1

Target: TCTN1 (Tectonic Family Member 1 (TCTN1))

Andere Bezeichnung: Tectonic-1

Hintergrund: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.Synonyms: TCTN1, TECT1

Gen-ID: 79600

NCBI Accession: NP_001076006

UniProt: Q2MV58

Pathways: Tube Formation