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TCTN1 Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TCTN1 in WB, IF und EIA. Er zeigt eine Reaktivität gegenüber Human und Maus.
Produktnummer ABIN783637

Kurzübersicht für TCTN1 Antikörper (N-Term) (ABIN783637)

Target

Alle TCTN1 Antikörper anzeigen
TCTN1 (Tectonic Family Member 1 (TCTN1))

Reaktivität

  • 16
  • 3
  • 2
Human, Maus

Wirt

  • 18
Kaninchen

Klonalität

  • 18
Polyklonal

Konjugat

  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser TCTN1 Antikörper ist unkonjugiert

Applikation

  • 18
  • 13
  • 13
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 2
    • 1
    • 1
    N-Term

    Spezifität

    This antibody detects TCTN1 . It is predicted to not cross-react with other TCTN members. Multiple isoforms are known to exist, this antibody recognizes isoforms 1 - 3.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, Mouse

    Aufreinigung

    Affinity chromatography purified via peptide column

    Immunogen

    15 amino acid peptide near the amino terminus of human TCTN1
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1.0 mg/mL

    Buffer

    PBS containing 0.02 % sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    TCTN1 (Tectonic Family Member 1 (TCTN1))

    Andere Bezeichnung

    Tectonic-1

    Hintergrund

    TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.Synonyms: TCTN1, TECT1

    Gen-ID

    79600

    NCBI Accession

    NP_001076006

    UniProt

    Q2MV58

    Pathways

    Tube Formation
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