RNF8 Antikörper (C-Term)

Produktnummer ABIN783604

Produktdetails anti-RNF8 Antikörper

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide near the carboxy terminus of human RNF8

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Details zu RNF8

Target: RNF8 (Ring Finger Protein 8 (RNF8))

Andere Bezeichnung: RNF8 (RNF8 Produkte)

Synonyme: hRNF8 antikoerper, 3830404E21Rik antikoerper, AIP37 antikoerper, RNF8 antikoerper, rnf8 antikoerper, fc66f09 antikoerper, wu:fc66f09 antikoerper, zgc:55936 antikoerper, zgc:77313 antikoerper, ring finger protein 8 antikoerper, ring finger protein 8, E3 ubiquitin protein ligase S homeolog antikoerper, ring finger protein 8, E3 ubiquitin protein ligase L homeolog antikoerper, ring finger protein 8, E3 ubiquitin protein ligase antikoerper, RNF8 antikoerper, Rnf8 antikoerper, rnf8.S antikoerper, rnf8.L antikoerper, rnf8 antikoerper

Hintergrund: RNF8 was identified as a ubiquitin ligase (E3) containing a RING finger motif and a FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes including UBE2E1/UBCH6, UBE2E2, and UBE2E3. RNF8 assembles at DNA double-strand breaks (DSBs) via interactions though the FHA domain with the adaptor protein MDC1, resulting in an increase in DSB-associated H2A histone ubiquitinations mediated by the associated ubiquitin ligase RNF168 followed by the accumulation of 53BP1 and BRCA1 repair proteins. Together with RNF168, RNF8 plays an integral part of class switch recombination in B cells, allowing the production of several classes of antibodies, through the recruitment of 53BP1 and BRCA1 to the DSB sites.Synonyms: E3 ubiquitin-protein ligase RNF8, RING finger protein 8

Gen-ID: 9025

NCBI Accession: NP_003949

UniProt: O76064

Pathways: Production of Molecular Mediator of Immune Response