OTUD5 Antikörper (C-Term)

Produktnummer ABIN783570

Dieses Anti-OTUD5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von OTUD5 in WB, IHC (p) und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für OTUD5 Antikörper (C-Term) (ABIN783570)

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OTUD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-OTUD5 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects OTUD5 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 13 amino acid peptide near the carboxy terminus of the human OTUD5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu OTUD5

Target: OTUD5 (OTU Domain Containing 5 (OTUD5))

Andere Bezeichnung: OTUD5

Hintergrund: OTUD5 is a member of the OTU (ovarian tumor) domain-containing cysteine protease superfamily. The OTU domain confers deubiquitinase activity and OTUD5 has been shown to suppress the type I interferon (IFN-I)-dependent innate immune response by cleaving the polyubiquitin chain from TRAF3, an essential type I interferon adaptor protein. Cleavage results in disassociation of TRAF3 from a downstream signaling complex containing TBK1 and the disruption of the IFN-I signaling cascade, indicating that OTUD5 acts as a negative regulator of innate immune responses. It has been suggested that by suppressing IFN-I production, OTUD5 may function to inhibit the emergence of certain autoimmune disorders such as systemic lupus erythematosus. Multiple isoforms of OTUD5 are known to exist.Synonyms: DUBA, Deubiquitinating enzyme A, OTU domain-containing protein 5

Gen-ID: 55593

NCBI Accession: NP_001129629

UniProt: Q96G74