VPS53 Antikörper (C-Term)

Produktnummer ABIN783564

Dieses Anti-VPS53-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von VPS53 in WB, IF und EIA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für VPS53 Antikörper (C-Term) (ABIN783564)

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-VPS53 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects VPS53 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the carboxy terminus of human VPS53

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu VPS53

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Andere Bezeichnung: VPS53

Hintergrund: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.Synonyms: PP13624, Vacuolar protein sorting-associated protein 53 homolog

Gen-ID: 55275

NCBI Accession: NP_001121631

UniProt: Q5VIR6