Transportin 3 Antikörper (N-Term)

Produktnummer ABIN783562

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Transportin 3 in WB und EIA. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Transportin 3 Antikörper (N-Term) (ABIN783562)

Target: Transportin 3 (TNPO3)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Transportin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-Transportin 3 Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody detects Transportin-3 (TNPO3) at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 18 amino acid peptide from near the amino terminus of human TNPO3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu Transportin 3

Target: Transportin 3 (TNPO3)

Andere Bezeichnung: Transportin-3 (TNPO3)

Hintergrund: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.Synonyms: IPO12, Imp12, Importin-12, TRN-SR, Transportin-SR

Gen-ID: 23534

NCBI Accession: NP_001177957

UniProt: Q9Y5L0

Pathways: Protein targeting to Nucleus