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GEMC1 Antikörper (Center)

GMNC Reaktivität: Human WB, EIA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN783498
  • Target Alle GEMC1 (GMNC) Antikörper anzeigen
    GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
    Bindungsspezifität
    Center
    Reaktivität
    • 1
    • 1
    Human
    Wirt
    • 1
    Kaninchen
    Klonalität
    • 1
    Polyklonal
    Konjugat
    • 1
    Dieser GEMC1 Antikörper ist unkonjugiert
    Applikation
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody detects GEMC1 at Center.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, mouse
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    19 amino acid peptide near the center of human GEMC1
    Top Product
    Discover our top product GMNC Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS containing 0.02 % sodium azi
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
  • Target
    GEMC1 (GMNC) (Geminin Coiled-Coil Domain Containing (GMNC))
    Andere Bezeichnung
    GEMC1 (GMNC Produkte)
    Synonyme
    GEMC1 antikoerper, Gemc1 antikoerper, Gm1778 antikoerper, Gm606 antikoerper, gemc1 antikoerper, xGEMC1 antikoerper, geminin coiled-coil domain containing antikoerper, geminin coiled-coil domain containing S homeolog antikoerper, GMNC antikoerper, Gmnc antikoerper, gmnc.S antikoerper
    Hintergrund
    The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication. GEMC1 contains a region similar to the coiled-coil domain of geminin, an essential vertebrate replication protein in which the coiled-coil domain is required for the function. GEMC1 binds to the checkpoint and replication factor TopBP1, allowing the binding of GEMC1 to chromatin during pre-replication complex formation. GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication. Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin, suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins.Synonyms: Geminin coiled-coil domain-containing protein 1
    Gen-ID
    647309
    NCBI Accession
    NP_001140158
    UniProt
    A6NCL1
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